Spontaneous regression of conjunctival keratoacanthoma.

An 83-year-old white man presented with a rapidly growing conjunctival mass in his left eye over the course of 1 month. While awaiting surgical intervention, the tumour underwent partial, spontaneous regression to half its original size. The lesion was ultimately excised with wide margins using a no-touch technique and application of cryotherapy to the corneal and conjunctival margins and scleral bed. Histopathological analysis revealed a conjunctival keratoacanthoma. To our knowledge, this is the first case documenting the partial, spontaneous regression of a conjunctival keratoacanthoma over a 5 week time course from the time of diagnosis to surgical excision.

Suplementos nutricionales como modificadores del riesgo cardiovascular en componentes del síndrome metabólico en adultos / Dietary supplements as modifiers of cardiovascular risk in components of the metabolic syndrome in adults

Resumen Objetivo: analizar los suplementos nutricionales con ácidos grasos de cadena larga, micronutrientes y antioxidantes en la población adulta, como posibles modificadores del riesgo cardiovascular en pacientes con diagnóstico de síndrome metabólico, o alguno de sus componentes. Métodos: Se realizó una revisión de la literatura en las bases de datos Medline y Embase, utilizando los términos ''Metabolic Syndrome'' AND ''Dietary supplements'' y 'Metabolic Syndrome'/exp AND 'Dietary supplement'/exp, respectivamente, sobre el papel de los suplementos nutricionales en la modificación del riesgo cardiovascular en adultos con síndrome metabólico o alguno de sus componentes. Resultados: De 475 artículos depurados, se seleccionaron 37 que estudiaran el posible beneficio de los suplementos nutricionales en el síndrome metabólico. Algunos estudios muestran un potencial de ácidos grasos de cadena larga y antioxidantes (vitamina D, vitamina E) para reducir el riesgo cardiovascular de pacientes con síndrome metabólico, evidenciado en la reducción de parámetros como colesterol total, glucemia, índice de masa corporal y perímetro abdominal. Conclusión: El uso de suplementos nutricionales con ácidos grasos de cadena larga y antioxidante podría tener efectos benéficos en la disminución de riesgo cardiovascular en pacientes con diagnóstico de síndrome metabólico o alguno de sus componentes. El uso de suplementos con otros componentes debe estudiarse a mayor profundidad para efectuar recomendaciones.

Abstract Objective: To analyze dietary supplements with long chain fatty acids, micronutrients and antioxidants in adult population as possible modifiers of cardiovascular risk in patients diagnosed with metabolic syndrome or any of its components. Methods: Literature review of databases Medline and Embase using terms ''Metabolic Syndrome'' AND ''Dietary supplements'' and 'Metabolic Syndrome'/exp AND 'Dietary supplement'/exp, respectively, on the role of dietary supplements in modifying cardiovascular risk in adults with metabolic syndrome or any of its components. Results: Out of 475 articles, the 37 selected studied the possible benefit of dietary supplements in metabolic syndrome. Some studies reveal a potential in long chain fatty acids and antioxidants (vitamin D, vitamin E) in reducing cardiovascular risk of patients with metabolic syndrome, evidenced in the decrease of parameters such as total cholesterol, blood sugar, body mass index and abdominal perimeter. Conclusion: The use of dietary supplements with long chain fatty acids and antioxidants could have beneficial effects in reducing cardiovascular risk in patients diagnosed with metabolic syndrome or any of its components. The use of supplements with other components must be studied more deeply to make further recommendations.